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TDT has developed marker tests which utilize RT PCR to amplify
the mRNA of a protein called Guanylyl Cyclase C (GCC). Dr. Waldman
and his research team have established that GCC is found only in
the mucosa of the intestine, and on colorectal cancer cells in extra-intestinal
sites. This establishes GCC as a highly selective marker for detecting
colorectal cancer metastases. Clinical studies have demonstrated
that GCC RT-PCR can detect a single cancer cell in 10,000,000 normal
cells.
Tests available include:
GCC Lymph Node
test - Detects metastatic cells in lymph nodes for accurately
staging patients.
GCC Blood Monitor
test - Detects circulating colorectal cancer cells in
patients undergoing post-treatment monitoring for recurrent disease.
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